DNA breaks in P288 tumor cells in mice after treatment with daunorubicin and adriamycin.

@article{Schwartz1975DNABI,
  title={DNA breaks in P288 tumor cells in mice after treatment with daunorubicin and adriamycin.},
  author={Herbert S. Schwartz},
  journal={Research communications in chemical pathology and pharmacology},
  year={1975},
  volume={10 1},
  pages={
          51-64
        }
}
Extensive DNA damage was found in tumor cells after therapeutic doses of daunorubicin and adriamycin (2.5 - 10 mg/kg) were administered to mice bearing lymphocytic leukemia (P-288). After low doses (0.6 mg/kg), DNA breaks were evident as early as 1-3 hr after daunorubicin and as determined with adriamycin the damage lasted as long as 72 hr. In a comparison, actinomycin D produced smaller amounts of damage by 3 hr after the administration of maximally tolerated doses (0.8 mg/kg) and even less… CONTINUE READING

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