DNA breaks in P288 tumor cells in mice after treatment with daunorubicin and adriamycin.

Abstract

Extensive DNA damage was found in tumor cells after therapeutic doses of daunorubicin and adriamycin (2.5 - 10 mg/kg) were administered to mice bearing lymphocytic leukemia (P-288). After low doses (0.6 mg/kg), DNA breaks were evident as early as 1-3 hr after daunorubicin and as determined with adriamycin the damage lasted as long as 72 hr. In a comparison… (More)

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Cite this paper

@article{Schwartz1975DNABI, title={DNA breaks in P288 tumor cells in mice after treatment with daunorubicin and adriamycin.}, author={Herbert S. Schwartz}, journal={Research communications in chemical pathology and pharmacology}, year={1975}, volume={10 1}, pages={51-64} }