DNA breaks and chromosome pulverization from errors in mitosis

@article{Crasta2012DNABA,
  title={DNA breaks and chromosome pulverization from errors in mitosis},
  author={Karen Crasta and Neil J Ganem and R. Dagher and Alexandra B. Lantermann and E. Ivanova and Yunfeng Pan and L. Nezi and A. Protopopov and D. Chowdhury and D. Pellman},
  journal={Nature},
  year={2012},
  volume={482},
  pages={53 - 58}
}
The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of debate, in large part because of the lack of insight into underlying mechanisms. Here we identify a mechanism by which errors in mitotic chromosome segregation generate DNA breaks via the formation of structures called micronuclei. Whole-chromosome-containing micronuclei form when mitotic errors produce lagging chromosomes. We tracked the fate of newly generated micronuclei and found that they undergo defective… Expand
846 Citations
Impaired nuclear functions in micronuclei results in genome instability and chromothripsis
  • 33
  • Highly Influenced
Micronuclei-based model system reveals functional consequences of chromothripsis in human cells
  • 7
  • Highly Influenced
  • PDF
Visualizing chromosomal rearrangements caused by replication fork stalling in a single cell
  • Highly Influenced
  • PDF
CHROMOTHRIPSIS FROM DNA DAMAGE IN MICRONUCLEI
  • 590
Cell biology: The micronucleus gets its big break
  • 4
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 59 REFERENCES
Chromosome missegregation in human cells arises through specific types of kinetochore–microtubule attachment errors
  • 188
  • PDF
Delayed replication timing leads to delayed mitotic chromosome condensation and chromosomal instability of chromosome translocations
  • L. Smith, A. Plug, M. Thayer
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
  • 83
  • PDF
Merotelic kinetochore orientation, aneuploidy, and cancer.
  • D. Cimini
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2008
  • 177
...
1
2
3
4
5
...