DNA breaks and chromosomal aberrations arise when replication meets base excision repair

@inproceedings{Ensminger2014DNABA,
  title={DNA breaks and chromosomal aberrations arise when replication meets base excision repair},
  author={Michael P Ensminger and Lucie Iloff and Christian Ebel and T. Nikolova and Bernd Kaina and Markus Lӧbrich},
  booktitle={The Journal of cell biology},
  year={2014}
}
Exposures that methylate DNA potently induce DNA double-strand breaks (DSBs) and chromosomal aberrations, which are thought to arise when damaged bases block DNA replication. Here, we demonstrate that DNA methylation damage causes DSB formation when replication interferes with base excision repair (BER), the predominant pathway for repairing methylated bases. We show that cells defective in the N-methylpurine DNA glycosylase, which fail to remove N-methylpurines from DNA and do not initiate BER… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Similar Papers

Loading similar papers…