DNA brain damage after stress in rats

  title={DNA brain damage after stress in rats},
  author={A. Consiglio and A. P. Ramos and J. Henriques and J. Picada},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • A. Consiglio, A. P. Ramos, +1 author J. Picada
  • Published 2010
  • Biology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • OBJECTIVE The purpose of this study was to verify the presence of DNA brain lesion after acute stress in rats. METHOD Adult male Wistar rats were divided into 3 groups according to the stressor (control, forced swimming or restraint), and sampled at 2 time points: immediately or 1week after stress. Trunk blood and the brain areas (prefrontal cortex, amygdala and hippocampus) were extracted for DNA analysis by the comet assay. The cells were classified according to the damage index and damage… CONTINUE READING
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