DNA-binding specificity of the homeodomain-leucine zipper domain.

@article{Sessa1997DNAbindingSO,
  title={DNA-binding specificity of the homeodomain-leucine zipper domain.},
  author={Guido Sessa and Giorgio Morelli and Ida Ruberti},
  journal={Journal of molecular biology},
  year={1997},
  volume={274 3},
  pages={
          303-9
        }
}
Homeodomain-leucine zipper (HD-Zip) proteins are putative transcription factors identified only in plants. The study of the DNA-binding properties of the ATHB-1 and -2 HD-Zip (HD-Zip-1 and -2) domains showed that they interact with DNA as homodimers and recognize two distinct 9 bp pseudopalindromic sequences, CAAT(A/T)ATTG (BS-1) and CAAT(G/C)ATTG (BS-2), respectively, as determined by selecting high-affinity binding sites from random-sequence DNA. Here, we report a mutational analysis of the… CONTINUE READING
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