DNA binding site specificity of the Neurospora global nitrogen regulatory protein NIT2: Analysis with mutated binding sites

@article{Chiang1994DNABS,
  title={DNA binding site specificity of the Neurospora global nitrogen regulatory protein NIT2: Analysis with mutated binding sites},
  author={Tso-Yu Chiang and Rajendra Rai and Terrance G. Cooper and George A. Marzluf},
  journal={Molecular and General Genetics MGG},
  year={1994},
  volume={245},
  pages={512-516}
}
NIT2, a positive-acting regulatory protein in Neurospora crassa, activates the expression of a series of unlinked structural genes that encode nitrogen catabolic enzymes. NIT2 binding sites in the promoter regions of nit3, alc and lao have at least two GATA sequence elements. We have examined the binding affinity of the NIT2 protein for the yeast DAL5 wild-type upstream activation sequence UASNTR, which contains two GATA elements, and for a series of mutated binding sites, each differing from… CONTINUE READING

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