DNA-binding proteins

@article{Ptashne1984DNAbindingP,
  title={DNA-binding proteins},
  author={Mark Ptashne},
  journal={Nature},
  year={1984},
  volume={308},
  pages={753-754}
}
• Job: to regulate transcription of DNA • The DNA – Phosphate backbone is uniform for the whole DNA molecule but there is a major and minor groove – Different chemical environment in the grooves depending on the base pairs at a particular site – base pairs especially exposed in the major groove • Example: helix-turn-helix binding motif – alpha helix then a turn then an alpha helix – forms a tertiary structure that fits well in the major groove – motif is seen frequently among DNA binding… CONTINUE READING
BETA