DNA binding properties of oligodeoxynucleotides containing pyrrolidino C-nucleosides.

Abstract

We have incorporated pyrrolidino-C-nucleosides (pyrrolidino-pseudonucleosides) containing the base uracil and N-1-methyl uracil into oligodeoxynucleotides and compared their thermal duplex and triplex stabilities with unmodified or pseudouridine-containing oligodeoxynucleotides. We find relative destabilizations of triplex formation by ca. -13 to -1 degrees… (More)

Topics

Cite this paper

@article{Hberli2002DNABP, title={DNA binding properties of oligodeoxynucleotides containing pyrrolidino C-nucleosides.}, author={Adrian H{\"a}berli and Christian J. Leumann}, journal={Organic letters}, year={2002}, volume={4 19}, pages={3275-8} }