DNA binding properties of novel cytotoxic gold(III) complexes of terpyridine ligands: the impact of steric and electrostatic effects

@article{Shi2006DNABP,
  title={DNA binding properties of novel cytotoxic gold(III) complexes of terpyridine ligands: the impact of steric and electrostatic effects},
  author={Pengfei Shi and Qin Jiang and Yongmei Zhao and Yangmiao Zhang and Jun Lin and Liping Lin and Jian Ding and Zijian Guo},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2006},
  volume={11},
  pages={745-752}
}
Four gold(III) complexes of terpyridine derivatives 1–4 have been synthesized and characterized by spectroscopic methods. In vitro data demonstrated that all of them showed higher cytotoxicity than cisplatin against the human non-small-cell lung cancer cell line (A-549), the human stomach carcinoma cell line (SGC-7901), the human cervix carcinoma cell line (HELA), the human colon carcinoma cell line (HCT-116), the human liver carcinoma cell line (BEL-7402), the murine leukemia cell line (P-388… CONTINUE READING

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