DNA-binding motif and target genes of the imprinted transcription factor PEG3.

@article{Thiaville2013DNAbindingMA,
  title={DNA-binding motif and target genes of the imprinted transcription factor PEG3.},
  author={Michelle M. Thiaville and Jennifer Marian Huang and Hana Kim and Muhammad B. Ekram and Tae-Young Roh and Joomyeong Kim},
  journal={Gene},
  year={2013},
  volume={512 2},
  pages={
          314-20
        }
}
The Peg3 gene is expressed only from the paternally inherited allele located on proximal mouse chromosome 7. The PEG3 protein encoded by this imprinted gene is predicted to bind DNA based on its multiple zinc finger motifs and nuclear localization. In the current study, we demonstrated PEG3's DNA-binding ability by characterizing its binding motif and target genes. We successfully identified target regions bound by PEG3 from mouse brain extracts using chromatin immunoprecipitation analysis… CONTINUE READING

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