DNA binding and transactivation properties of the Schistosoma mansoni constitutive androstane receptor homologue.

@article{Hu2006DNABA,
  title={DNA binding and transactivation properties of the Schistosoma mansoni constitutive androstane receptor homologue.},
  author={Rong Hu and Edward G. Niles and Philip T. Loverde},
  journal={Molecular and biochemical parasitology},
  year={2006},
  volume={150 2},
  pages={174-85}
}
SmCAR (Schistosoma mansoni constitutive androstane receptor) is a schistosome homologue of the CAR/PXR/VDR group of nuclear receptors. The P box sequence in the DNA binding domain (DBD) of SmCAR, which is essential in determining the DNA binding specificity of nuclear receptors, is different from its vertebrate homologues. Previous data demonstrates that SmCAR binds to a hormone response element containing a single half site AGTGCA as a monomer. SmRXR1 and SmRXR2 are two S. mansoni homologues… CONTINUE READING

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