DNA binding and nuclear translocation of insect high-mobility-group- protein-1 (HMG1) proteins are inhibited by phosphorylation.

@article{Wisniewski1994DNABA,
  title={DNA binding and nuclear translocation of insect high-mobility-group- protein-1 (HMG1) proteins are inhibited by phosphorylation.},
  author={Jacek R. Wisniewski and E. D. Von Schulze and B Sapetto},
  journal={European journal of biochemistry},
  year={1994},
  volume={225 2},
  pages={
          687-93
        }
}
The cells of the dipteran insects Chironomus and Drosophila contain high-mobility-group proteins (HMG) that are homologous to the HMG1 proteins of mammals, but contain only one HMG1 box instead of two. The C-terminal portions of both mammalian and insect HMG1 proteins comprise many charged residues that modulate the DNA-binding affinity of the HMG1 boxes and were found in Chironomus to be substrates for protein kinase C (PKC) in vitro and in vivo. Phosphorylation of Chironomus HMG1 proteins… CONTINUE READING

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