DNA binding and inhibition of DNA synthesis after 7,12-dimethylbenz(a)anthracene administered during the early prereplicative phase in regenerating rat liver.


We have previously reported that 7,12-dimethylbenz(a)an thracene (DMBA), given i.v. 24 hr after partial hepatectomy when DNA replication is maximal, binds tightly to DNA, inhibits its synthesis, and induces neoplastic changes in regenerating rat liver. We now report that DMBA injected i.v. 5 hr after partial hepatectomy (i.e., during the early… (More)

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