DNA-binding and disposition of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in the rat.

@article{Dragsted1995DNAbindingAD,
  title={DNA-binding and disposition of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in the rat.},
  author={Lars Ove Dragsted and Henrik Frandsen and Ragnhild Reistad and Jan Alexander and John Christian Larsen},
  journal={Carcinogenesis},
  year={1995},
  volume={16 11},
  pages={2785-93}
}
Untreated and Aroclor 1254-pretreated male Wistar rats were given a single dose of 1.0 mg/kg body weight of randomly tritium-labelled 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (3H-PhIP) by oral intubation. Urine and faeces were collected at 24, 48 and 72 hours after dosing, and total radioactivity determined. At 2, 4, 6, 16, 26, 48 and 72 h, animals were killed and several organs, including liver, bladder, lungs, kidney, stomach, large and small intestines, heart, thigh muscles, spleen… CONTINUE READING

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DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

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