DNA binding and cleaving activity of the new cleft molecule N,N'-Bis(guanidinoethyl)-2,6-pyridinedicarboxamide in the absence or in the presence of copper(II).

Abstract

Novel cleft molecule pyridine-2,6-dicarboxamide appending two guanidinoethyl group side arms (Gua) was synthesized. The interactions of the cleft molecule in the absence of copper(II) (Gua) or in the presence of copper(II) (Cu2+-Gua) with calf thymus DNA were studied by fluorescence and CD spectroscopy. The results indicate that the DNA binding affinity of… (More)
DOI: 10.1021/bc800062g

Topics

Cite this paper

@article{Shao2008DNABA, title={DNA binding and cleaving activity of the new cleft molecule N,N'-Bis(guanidinoethyl)-2,6-pyridinedicarboxamide in the absence or in the presence of copper(II).}, author={Ying Shao and Xin Sheng and Ying Li and Zhao-Li Jia and Jing-jing Zhang and Fang Sheng Liu and Guo-yuan Lu}, journal={Bioconjugate chemistry}, year={2008}, volume={19 9}, pages={1840-8} }