DNA binding analysis of glucocorticoid receptor specificity mutants.

@article{Alroy1992DNABA,
  title={DNA binding analysis of glucocorticoid receptor specificity mutants.},
  author={Iris Alroy and Leonard P. Freedman},
  journal={Nucleic acids research},
  year={1992},
  volume={20 5},
  pages={1045-52}
}
The glucocorticoid receptor (GR) DNA binding domain consists of several conserved amino acids and folds into two zinc finger-like structures. Previous transactivation experiments indicated that three amino acids residing in this region, Gly, Ser and Val, appear to be critical for target-site discrimination. Based on the solved crystal structure, these residues are at the beginning of an amphipathic alpha-helix that interacts with the DNA's major groove; of these, only valine, however, contacts… CONTINUE READING

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