DNA binding analysis of glucocorticoid receptor specificity mutants.

  title={DNA binding analysis of glucocorticoid receptor specificity mutants.},
  author={Iris Alroy and Leonard P. Freedman},
  journal={Nucleic acids research},
  volume={20 5},
The glucocorticoid receptor (GR) DNA binding domain consists of several conserved amino acids and folds into two zinc finger-like structures. Previous transactivation experiments indicated that three amino acids residing in this region, Gly, Ser and Val, appear to be critical for target-site discrimination. Based on the solved crystal structure, these residues are at the beginning of an amphipathic alpha-helix that interacts with the DNA's major groove; of these, only valine, however, contacts… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 16 references

Faseb J

  • W Wahli, E Martinez
  • 1991

J. Bioi Chem

  • A M Nardulli, D Lew, L Erijman, Dj Shapiro
  • J. Bioi Chem
  • 1991

J. Biol. Chem

  • K Dahlman-Wright, A Wright, J-A Gustafcson, J Castedt-Duke
  • J. Biol. Chem
  • 1991

Mol. Cell. Biol

  • M Truss, G Chalepakis, E P Slater, S Mader, M Beato
  • Mol. Cell. Biol
  • 1991

Molec. Endocrinol

  • L P Freedman, T L Towers
  • Molec. Endocrinol
  • 1991


  • J W R Schwabe, D Neuhaus, D Rhodes
  • 1990

Mol. Endocrinol

  • O Malley
  • Mol. Endocrinol
  • 1990


  • M Bcato
  • Cell
  • 1989

Cell Cell

  • M Danielson, L Hinck, Andg M Umesono, R M Evans
  • Cell Cell
  • 1989

Genes Develop

  • M Schena, L P Freedman, K R Yamamoto
  • Genes Develop
  • 1989

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