DNA bending and its relation to nucleosome positioning.

  title={DNA bending and its relation to nucleosome positioning.},
  author={Horace R. Drew and Andrew Travers},
  journal={Journal of molecular biology},
  volume={186 4},
X-ray and solution studies have shown that the conformation of a DNA double helix depends strongly on its base sequence. Here we show that certain sequence-dependent modulations in structure appear to determine the rotational positioning of DNA about the nucleosome. Three different experiments are described. First, a piece of DNA of defined sequence (169 base-pairs long) is closed into a circle, and its structure examined by digestion with DNAase I: the helix adopts a highly preferred… CONTINUE READING
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