DNA base-excision repair enzyme apurinic/apyrimidinic endonuclease/redox factor-1 is increased and competent in the brain and spinal cord of individuals with amyotrophic lateral sclerosis

@article{Shaikh2002DNABR,
  title={DNA base-excision repair enzyme apurinic/apyrimidinic endonuclease/redox factor-1 is increased and competent in the brain and spinal cord of individuals with amyotrophic lateral sclerosis},
  author={Arif Y. Shaikh and Lee J. Martin},
  journal={NeuroMolecular Medicine},
  year={2002},
  volume={2},
  pages={47-60}
}
Motor neurons degenerate in amyotrophic lateral sclerosis (ALS). The mechanisms for this neuronal cell death are not known, although apoptosis has been implicated. Oxidative damage to DNA and activation of p53 has been identified directly in motor neurons in cases of ALS. We evaluated whether motor neuron degeneration in ALS is associated with changes in the levels and function of the multifunctional protein apurinic/apyrimidinic enodnuclease (APE/Ref-1). APE/Ref-1 functions as an enzyme in the… CONTINUE READING
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