DNA base excision repair as a biomarker in molecular epidemiology studies.

@article{Collins2007DNABE,
  title={DNA base excision repair as a biomarker in molecular epidemiology studies.},
  author={Andrew R Collins and I. O. M. Gaiv{\~a}o},
  journal={Molecular aspects of medicine},
  year={2007},
  volume={28 3-4},
  pages={307-22}
}
Base excision repair can be measured in human lymphocytes by a variety of techniques, the most convenient of which are probably in vitro assays of the activity of a cell extract on a DNA substrate containing specific lesions such as 8-oxoguanine. Inter-individual variation in base excision repair ranges from about 3-fold to 10-fold in different studies. Repair has been variously reported to decline or to increase with the age of the individual. Few studies of environmental or occupational… CONTINUE READING

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