DNA base excision repair and nucleotide excision repair synergistically contribute to survival of stationary‐phase cells of the fission yeast Schizosaccharomyces pombe

@article{Senoo2017DNABE,
  title={DNA base excision repair and nucleotide excision repair synergistically contribute to survival of stationary‐phase cells of the fission yeast Schizosaccharomyces pombe},
  author={Takanori Senoo and S. Kawano and S. Ikeda},
  journal={Cell Biology International},
  year={2017},
  volume={41}
}
Defects of genome maintenance may causally contribute to aging. In general, base excision repair (BER) is involved in the repair of subtle base lesions and AP sites, and bulky helix‐distorting lesions are restored by nucleotide excision repair (NER). Here, we measured the chronological lifespan (CLS) of BER‐ and NER‐deficient mutants of the fission yeast Schizosaccharomyces pombe, and observed the aging process of cells. The CLS of the nth1 (gene for DNA glycosylase/AP lyase) mutant and the… Expand
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