DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation.

  title={DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation.},
  author={Jean Cadet and J. Richard Wagner},
  journal={Cold Spring Harbor perspectives in biology},
  volume={5 2}
Emphasis has been placed in this article dedicated to DNA damage on recent aspects of the formation and measurement of oxidatively generated damage in cellular DNA in order to provide a comprehensive and updated survey. This includes single pyrimidine and purine base lesions, intrastrand cross-links, purine 5',8-cyclonucleosides, DNA-protein adducts and interstrand cross-links formed by the reactions of either the nucleobases or the 2-deoxyribose moiety with the hydroxyl radical, one-electron… CONTINUE READING
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