DNA aneuploidy in adult acute leukemia.

  title={DNA aneuploidy in adult acute leukemia.},
  author={Bart Barlogie and Sanford A. Stass and Dennis Dixon and Michael J Keating and Ann C Cork and Jose Maria Trujillo and Kenneth B. McCredie and Emil J. Freireich},
  journal={Cancer genetics and cytogenetics},
  volume={28 2},
Using flow cytometric techniques, we determined DNA ploidy levels in the bone marrow of 318 successive adult patients with newly diagnosed acute leukemia. Overall, 26% exhibited DNA stem line abnormalities, usually with a 10%-15% DNA excess, regardless of morphologic diagnosis. DNA aneuploidy was seen most frequently in patients with a hyperdiploid chromosome number and karyotype instability (50%), but was also present in a third of patients with chromosomal translocations and in 20% of… CONTINUE READING

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