DNA and a CpG oligonucleotide derived from Babesia bovis are mitogenic for bovine B cells.

@article{Brown1998DNAAA,
  title={DNA and a CpG oligonucleotide derived from Babesia bovis are mitogenic for bovine B cells.},
  author={Wendy C. Brown and Dr. Mary K. Estes and S E Chantler and Kimberly A. Kegerreis and Carlos Esteban Suarez},
  journal={Infection and immunity},
  year={1998},
  volume={66 11},
  pages={5423-32}
}
DNAs from bacteria and variety of nonvertebrate organisms, including nematodes, mollusks, yeasts, and insects, cause polyclonal activation of murine B lymphocytes. Similar studies have not been reported for bovine B cells, and to date no studies have reported mitogenic properties of protozoal DNA for any species. However, we and others have observed that protozoal parasite antigens can induce the proliferation of lymphocytes from nonexposed donors. Extending these studies, we now show that the… CONTINUE READING

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