DNA and RNA-based vaccines: principles, progress and prospects.

@article{Leitner1999DNAAR,
  title={DNA and RNA-based vaccines: principles, progress and prospects.},
  author={W. Leitner and Han Ying and Nicholas P Restifo},
  journal={Vaccine},
  year={1999},
  volume={18 9-10},
  pages={765-77}
}
DNA vaccines were introduced less than a decade ago but have already been applied to a wide range of infectious and malignant diseases. Here we review the current understanding of the mechanisms underlying the activities of these new vaccines. We focus on recent strategies designed to enhance their function including the use of immunostimulatory (CpG) sequences, dendritic cells (DC), co-stimulatory molecules and cytokine- and chemokine-adjuvants. Although genetic vaccines have been… CONTINUE READING

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