DNA and RNA Modified Dendritic Cell Vaccines

@article{Morse2002DNAAR,
  title={DNA and RNA Modified Dendritic Cell Vaccines},
  author={Michael Andew Morse and H Kim Lyerly},
  journal={World Journal of Surgery},
  year={2002},
  volume={26},
  pages={819-825}
}
The purpose of this paper is to describe the strategies for genetic modification of dendritic cells for use in active immunotherapy for the treatment of malignancies. An accruing body of data supports the concept of directing a therapeutic immune response, mediated by the cellular arm of the immune system, against cancers in vivo. Dendritic cells are the most potent inducers of T cell-mediated immune responses against tumor-expressed antigens, by virtue of their ability to present tumor… CONTINUE READING

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