DNA analysis of Huntington's disease in southern Chinese.

@article{Chan1995DNAAO,
  title={DNA analysis of Huntington's disease in southern Chinese.},
  author={Vivian Chan and Yuan Long Yu and T P Chan and Ben H Yip and Chun-Ju Chang and Michael Tl Wong and Yuk Wai Chan and Tat Keong Chan},
  journal={Journal of medical genetics},
  year={1995},
  volume={32 2},
  pages={120-4}
}
Allelic frequencies of RFLPs at loci closely linked to the HD gene, D4S95, D4S91, D4S141, and D4S90, were determined in 13 Huntington's disease (HD) patients from nine Chinese families and 129 normal subjects. These were similar for non-HD and HD chromosomes and the HD gene in Chinese is associated with multiple haplotypes. Hence the HD gene probably arose independently in the background haplotypes of the Chinese population. The heterozygosity rates for the two most useful RFLP sites are 0.659… CONTINUE READING
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