DNA alterations at proto-oncogene loci and their clinical significance in operable non-small cell lung cancer.

Abstract

DNA from tumor samples of 54 patients with operable non-small cell lung cancer (NSCLC) was analyzed to determine whether proto-oncogene alterations could be correlated with the clinical behavior of lung cancer. Among seven proto-oncogenes tested, changes in the copy number of Ha-ras, c-myc and c-raf-1 were found in only seven tumors. Most of them were epidermoid carcinomas without lymph node involvement (N0). In spite of a localized disease with complete surgical resection, six of these patients relapsed within a mean disease-free interval (DFI) of only 6.5 months. There is a significant correlation between DNA alterations at proto-oncogene loci and clinical relapse within 12 months of surgical resection (P less than 0.025).

Cite this paper

@article{Hajj1990DNAAA, title={DNA alterations at proto-oncogene loci and their clinical significance in operable non-small cell lung cancer.}, author={Carla Hajj and Riad Akoum and Erik Bradley and Fr{\'e}d{\'e}rique Paquin and Joseph I. G. Ayoub}, journal={Cancer}, year={1990}, volume={66 4}, pages={733-9} }