DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis.

@article{Schut1999DNAAO,
  title={DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis.},
  author={H. Schut and E. Snyderwine},
  journal={Carcinogenesis},
  year={1999},
  volume={20 3},
  pages={
          353-68
        }
}
The heterocyclic amines (HCAs) are a family of mutagenic/carcinogenic compounds produced during the pyrolysis of creatine, amino acids and proteins. The major subclass of HCAs found in the human diet comprise the aminoimidazoazaarenes (AIAs) 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b… Expand
319 Citations
Mutagenicity of Food-Derived Carcinogens and the Effect of Antioxidant Vitamins
  • 8
DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.
  • 57
Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells.
  • M. Pezdirc, B. Žegura, M. Filipič
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2013
  • 34
Acid-labile protein-adducted heterocyclic aromatic amines in human blood are not viable biomarkers of dietary exposure: A systematic study.
  • K. M. Cooper, S. Brennan, +5 authors G. Cuskelly
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2016
  • 2
  • Highly Influenced
  • PDF
In silico prediction of Heterocyclic Aromatic Amines metabolism susceptible to form DNA adducts in humans.
  • 3
  • Highly Influenced
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 348 REFERENCES
Metabolic processing and carcinogenicity of heterocyclic amines in nonhuman primates.
  • 41
Quantitation of mutagenic/carcinogenic heterocyclic aromatic amines in food products.
  • 370
Genotoxicity of heterocyclic amines in the Salmonella/hepatocyte system.
  • 19
...
1
2
3
4
5
...