DNA adducts formed by ring-oxidation of the carcinogen 2-naphthylamine with prostaglandin H synthase in vitro and in the dog urothelium in vivo.

@article{Yamazoe1985DNAAF,
  title={DNA adducts formed by ring-oxidation of the carcinogen 2-naphthylamine with prostaglandin H synthase in vitro and in the dog urothelium in vivo.},
  author={Y. Yamazoe and D. Miller and C. Weis and K. Dooley and T. Zenser and F. Beland and F. Kadlubar},
  journal={Carcinogenesis},
  year={1985},
  volume={6 9},
  pages={
          1379-87
        }
}
The presence of relatively high levels of prostaglandin H synthase (PHS) in the dog urinary bladder and its ability to mediate the activation of carcinogenic arylamines to DNA-bound products in vitro suggests the involvement of this enzyme in arylamine-induced bladder carcinogenesis. Since the PHS-dependent metabolism of 2-naphthylamine (2-NA) had been shown to yield both ring- and N-oxidation products in vitro, we compared the reactivity of 3H-labeled N-hydroxy-2-naphthylamine (N-OH-2-NA), 2… Expand
Prostaglandin H synthase-catalyzed metabolism and DNA binding of 2-naphthylamine.
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