DNA adducts derived from administration of acrylamide and glycidamide to mice and rats.

@article{Doerge2005DNAAD,
  title={DNA adducts derived from administration of acrylamide and glycidamide to mice and rats.},
  author={Daniel R. Doerge and Gonçalo Gamboa da Costa and Lea P. McDaniel and Mona I. Churchwell and Nathan C. Twaddle and Frederick A Beland},
  journal={Mutation research},
  year={2005},
  volume={580 1-2},
  pages={131-41}
}
Acrylamide (AA) is an important industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in chronic rodent bioassays. Recent findings of AA in many common starchy foods have sparked renewed interest in determining toxic mechanisms and in understanding the cancer, neurotoxicity, and reproductive risks from typical human exposures. Dosing mice and rats with AA (50 mg/kg) led to presence of glycidamide (GA) in serum and tissues. Furthermore, GA-derived DNA… CONTINUE READING

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