• Corpus ID: 35878388

DNA adduct formation in relation to tumorigenesis in mice chronically fed 2-acetylaminofluorene.

@article{Beland1990DNAAF,
  title={DNA adduct formation in relation to tumorigenesis in mice chronically fed 2-acetylaminofluorene.},
  author={Frederick A Beland and Nancy F. Fullerton and Takemi Kinouchi and B. A. Smith and Miriam C. Poirier},
  journal={Progress in clinical and biological research},
  year={1990},
  volume={331},
  pages={
          121-9; discussion 147-8
        }
}
Urinary Bladder Carcinogenesis by DNA Reactive and Non-Reactive Chemicals: Non-Linearities and Thresholds
TLDR
Increasing evidence strongly supports the concept of thresholds in carcinogenesis, not only for chemicals acting by increasing cell proliferation but also for those acting by DNA reactivity.
Aromatic amines: mechanisms of carcinogenesis and implications for risk assessment.
  • H. Neumann
  • Environmental Science
    Frontiers in bioscience
  • 2010
TLDR
The ALARA principle (as low as reasonably achievable) is part of such an approach but it does not say how much exposure is acceptable.
Thresholds in Genotoxicity and Carcinogenicity : Urinary Bladder Carcinogenesis
TLDR
Cytotoxicity can be produced by formation of urinary solids or by urinary reactive chemicals, which has a threshold dose response with respect to carcinogenesis, as do most genotoxic agents.
Aromatic Amines in Experimental Cancer Research: Tissue-Specific Effects, an Old Problem and New Solutions
  • H. Neumann
  • Biology
    Critical reviews in toxicology
  • 2007
TLDR
A hypothesis is presented that explains the mode of action in this rat liver model of 2-acetylaminofluorene and allows a more comprehensive view of the complex in vivo situation at a time when in vitro models prevail.
DNA Adducts and Their Consequences
1. the majority of carcinogens are also mutagens; 2. the mutagenic and carcinogenic properties of many carcinogens depend upon their conversion to electrophilic derivatives that react with
Biomarkers as Molecular Dosimeters of Genotoxic Substances
TLDR
Exposure to genotoxic carcinogens results in the formation of covalently bound adducts between the genotoxin and DNA, which may cause mutation and cytogenetic alterations, and measurement of the former may indicate the biologically-effective dose of the compound received.
Mathematical models for the initiating and promotive action of carcinogens
Risk limitation has become an important issue to the public, administrators, and politicians in most societies. Systems for risk limitation have therefore been built up, particularly in
DNA Adduct Formation During Chronic Administration of an Aromatic Amine
TLDR
Two studies suggest that initiating events involving DNA adducts occur relatively early in the carcinogenic process, and that cells progressing to form tumors may not necessarily contain or be able to form DNAAdducts.