DNA adduct formation by ochratoxin A: review of the available evidence.

@article{Mally2005DNAAF,
  title={DNA adduct formation by ochratoxin A: review of the available evidence.},
  author={Angela Mally and Wolfgang Dekant},
  journal={Food additives and contaminants},
  year={2005},
  volume={22 Suppl 1},
  pages={65-74}
}
The mycotoxin ochratoxin A (OTA) is a potent nephrotoxin and renal carcinogen in rodents. However, the mechanism of OTA-induced tumour formation is unknown and conflicting results regarding the potential of OTA to react with DNA have been obtained. While experiments using radiolabelled ((3)H or (14)C) OTA and liquid scintillation counting or accelerator mass spectrometry indicate lack of formation of covalent DNA-adducts, spots detected by (32)P-postlabelling have been attributed to treatment… CONTINUE READING