DNA adduct formation and mutation induction by nitropyrenes in Salmonella and Chinese hamster ovary cells: relationships with nitroreduction and acetylation.

@article{Heflich1985DNAAF,
  title={DNA adduct formation and mutation induction by nitropyrenes in Salmonella and Chinese hamster ovary cells: relationships with nitroreduction and acetylation.},
  author={R. Heflich and E. K. Fifer and Z. Djuri{\'c} and F. Beland},
  journal={Environmental Health Perspectives},
  year={1985},
  volume={62},
  pages={135 - 143}
}
Nitrated pyrenes are environmental pollutants and potent mutagens in the Salmonella reversion assay. In this study reversion induction by 1-nitropyrene and 1,8-dinitropyrene in Salmonella typhimurium TA1538 and mutation induction by 1-nitropyrene in Chinese hamster ovary (CHO) cells were related to the extent of metabolism and DNA adduct formation. In suspension cultures of Salmonella typhimurium TA1538, 1,8-dinitropyrene was up to 40-fold more mutagenic than 1-nitropyrene, although both… Expand
Metabolic activation of 1-nitropyrene to a mammalian cell mutagen and a carcinogen.
Aerobic and anaerobic reduction of nitrated pyrenes in vitro.
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