DNA Word Design Strategy for Creating Sets of Non-interacting Oligonucleotides for DNA Microarrays

@inproceedings{LiDNAWD,
  title={DNA Word Design Strategy for Creating Sets of Non-interacting Oligonucleotides for DNA Microarrays},
  author={Ming Li and Hye Jin Lee and Anne E. Condon and Robert M. Corn}
}
A template-map design strategy for generating sets of non-interacting DNA oligonucleotides for applications in DNA arrays and biosensors is demonstrated. This strategy is used to create a set of oligonucleotides of size s with length l that possess at least n base mismatches with the complements of all the other members in the set. These “DNA word” sets are denoted as nbm l-mers or l:n sets. To regularize the thermodynamic stability of the perfectly matched hybridized DNA duplexes, the l-mers… CONTINUE READING

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