DNA Vaccine against Hamster Oral Papillomavirus-associated Oral Cancer

  title={DNA Vaccine against Hamster Oral Papillomavirus-associated Oral Cancer},
  author={H. Maeda and Katsutoshi Kubo and Y. Sugita and Y. Miyamoto and Shinichi Komatsu and S. Takeuchi and T. Umebayashi and Shinsaku Morikawa and K. Kawanishi and Y. Kameyama},
  journal={Journal of International Medical Research},
  pages={647 - 653}
  • H. Maeda, Katsutoshi Kubo, +7 authors Y. Kameyama
  • Published 2005
  • Medicine
  • Journal of International Medical Research
  • Previously we developed a carcinogenesis model involving the combination of 9, 10-dimethyl-1, 2-benzanthracene (DMBA) application with physical wounding of hamster lingual mucosa. The presence of a novel hamster oral papillomavirus (HOPV) was demonstrated and its genome sequenced. In the present study, this HOPV hamster model was used to test whether vaccination with the L1 gene could prevent the development of oral carcinoma. DNA plasmids encoding the L1 gene or the vector alone were injected… CONTINUE READING
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