DNA Topoisomerase VI Generates ATP-dependent Double-strand Breaks with Two-nucleotide Overhangs*

@article{Buhler2001DNATV,
  title={DNA Topoisomerase VI Generates ATP-dependent Double-strand Breaks with Two-nucleotide Overhangs*},
  author={C. Buhler and J. Lebbink and C. Bocs and R. Ladenstein and P. Forterre},
  journal={The Journal of Biological Chemistry},
  year={2001},
  volume={276},
  pages={37215 - 37222}
}
A key step in the DNA transport by type II DNA topoisomerase is the formation of a double-strand break with the enzyme being covalently linked to the broken DNA ends (referred to as the cleavage complex). In the present study, we have analyzed the formation and structure of the cleavage complex catalyzed by Sufolobus shibatae DNA topoisomerase VI (topoVI), a member of the recently described type IIB DNA topoisomerase family. A purification procedure of a fully soluble recombinant topoVI was… Expand
The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks
Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI
Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage
New mechanistic and functional insights into DNA topoisomerases.
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