DNA Topoisomerase II Modulates Insulator Function in Drosophila

  title={DNA Topoisomerase II Modulates Insulator Function in Drosophila},
  author={Edward Ramos and Eduardo A. Torre and Ashley M. Bushey and Baraka V Gurudatta and Victor G Corces},
  booktitle={PloS one},
Insulators are DNA sequences thought to be important for the establishment and maintenance of cell-type specific nuclear architecture. In Drosophila there are several classes of insulators that appear to have unique roles in gene expression. The mechanisms involved in determining and regulating the specific roles of these insulator classes are not understood. Here we report that DNA Topoisomerase II modulates the activity of the Su(Hw) insulator. Downregulation of Topo II by RNAi or mutations… CONTINUE READING
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