DNA Study Forces Rethink of What It Means to Be a Gene

  title={DNA Study Forces Rethink of What It Means to Be a Gene},
  author={Elizabeth Pennisi},
  pages={1556 - 1557}
According to a painstaking new analysis of 1% of the human genome, genes can be sprawling, with far-flung protein-coding and regulatory regions that overlap with other genes. 
Unraveling genetic regulatory networks of mammalian retroelements
Major findings in the laboratory defining the molecular basis of L1 retroelement activation in mammalian cells and the architecture of gene regulatory networks involved in phenotypic control are summarized. Expand
Defining genes: a computational framework
A definition of the gene within a computational framework of cellular interactions is introduced to satisfy the practical requirements imposed by annotation, capture logical aspects of regulation, and encompass the evolutionary property of homology. Expand
Complexity of Mammalian Transcriptome Analyzed by RNA Deep Sequencing
Researchers discovered that pieces of long DNA molecules, called genes, are recognized by the nuclear multi-subunit complex of ribonucleic acid (RNA) polymerase, which then produces molecules of RNA, complementarily mirroring the original DNA. Expand
Noncoding DNA is not "junk" but a necessity for origin and evolution of biological complexity
A comprehensive understanding of the significance of noncoding DNA sequences in eukaryotic genomes is essential for understanding the origin and sustenance of complex biological organization of multicellular organisms. Expand
Basics of Molecular Biology
Molecular biology chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interactions Between DNA, RNA, RNA and protein biosynthesis, as well as learning how these interactions are regulated. Expand
Molecular genetic studies on nemaline myopathy and related disorders
The present work aims to clarify the genomic organisation of human and other organisms by elucidating the sequence-by-sequence relationships between genes, proteins, and polymorphisms. Expand
Sequence variability and sequence evolution: an explanation of molecular polymorphisms and why many molecular structures can be preserved although they are not predominant.
  • B. Arneth
  • Biology, Medicine
  • DNA and cell biology
  • 2010
The extent to which the cell may undergo evolutionary processes that also occur in the macrocosmos, specifically with reference to the rules of mutation and preservation is demonstrated. Expand
Genome characterization through dichotomic classes: an analysis of the whole chromosome 1 of A. thaliana.
The present work confirms that the recent mathematical model of the genetic code is a new paradigm for understanding the management and the organization of genetic information and is an innovative tool for investigating informational aspects of error detection/correction mechanisms acting at the level of DNA replication. Expand
Investigation of the cellular significance of long non-coding RNA NEAT1 and paraspeckles
It is found that as cells transition from pluripotency to a differentiated state, epigenetic silencing of NEAT1 is gradually lost, replaced with an epigenetic signature indicative of a highly active state of transcription, which explains why NEAT 1 is expressed in differentiated, but not pluripotent cells. Expand