DNA Single-Strand Break Repair and Spinocerebellar Ataxia

  title={DNA Single-Strand Break Repair and Spinocerebellar Ataxia},
  author={Keith W. Caldecott},
DNA single-strand break repair (SSBR) is critical for the survival and genetic stability of mammalian cells. Three papers have recently associated mutations in putative human SSBR genes with hereditary spinocerebellar ataxia. The emerging links between SSBR and neurodegenerative disorders are discussed. 
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