DNA Replication-A Matter of Fidelity.

Abstract

The fidelity of DNA replication is determined by many factors, here simplified as the contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch repair, a balanced supply of nucleotides, and the condition of the DNA template (both in terms of sequence context and the presence of DNA lesions). This review discusses the… (More)
DOI: 10.1016/j.molcel.2016.05.003

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