DNA Repair in Mammalian Cells

  title={DNA Repair in Mammalian Cells},
  author={Silvia Tornaletti},
  journal={Cellular and Molecular Life Sciences},
Arrest of transcription at sites of DNA damage represents a strong signal for apoptosis. To overcome the impasse represented by transcription complexes arrested at sites of damage, cells have evolved a specialized nucleotide excision repair (NER) pathway called transcription-coupled DNA repair (TCR), dedicated to removal of transcription-blocking lesions from the genome. This repair pathway was discovered in Phil Hanawalt’s laboratory 20 years ago, but the mechanistic details are still subject… CONTINUE READING
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