DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity

@inproceedings{Chuang2013DNAPB,
  title={DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity},
  author={Ilin Chuang and Martha Sedegah and Susan Cicatelli and Michele D. Spring and Mark E. Polhemus and Cindy L. Tamminga and Noelle B. Patterson and Melanie Guerrero and Jason W. Bennett and Shannon McGrath and Harini D. Ganeshan and Maria Jesus Maldonado Belmonte and Fouzia Farooq and Esteban N. Abot and Jo Glenna Banania and Jun Huang and Rhonda L Newcomer and Lisa Rein and Dianne D. Litilit and Nancy O. Richie and Chloe L Wood and Jittawadee R Murphy and Robert W. Sauerwein and Cornelus Hermsen and Andrea J. McCoy and Edwin Kamau and James Cummings and Jack L Komisar and Awalludin Sutamihardja and Meng Shi and Judith E. Epstein and Santina Maiolatesi and Donna Tosh and Keith Limbach and Evelina Angov and Elke S Bergmann-Leitner and Joseph T. Bruder and Denise L. Doolan and C. Richter King and Daniel J. Carucci and Sheetij Dutta and Lorraine A. Soisson and Carter L. Diggs and Michael R Hollingdale and Christian F. Ockenhouse and Thomas L. Richie},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Gene-based vaccination using prime/boost regimens protects animals and humans against malaria, inducing cell-mediated responses that in animal models target liver stage malaria parasites. We tested a DNA prime/adenovirus boost malaria vaccine in a Phase 1 clinical trial with controlled human malaria infection. METHODOLOGY/PRINCIPAL FINDINGS The vaccine regimen was three monthly doses of two DNA plasmids (DNA) followed four months later by a single boost with two non-replicating… CONTINUE READING
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Malaria Vaccines: Recent Advances and New Horizons

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