DNA Polymerase α Subunit Residues and Interactions Required for Efficient Initiation Complex Formation Identified by a Genetic Selection.

@article{Lindow2015DNAP,
  title={DNA Polymerase α Subunit Residues and Interactions Required for Efficient Initiation Complex Formation Identified by a Genetic Selection.},
  author={Janet C. Lindow and Paul R Dohrmann and Charles S McHenry},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 27},
  pages={
          16851-60
        }
}
Biophysical and structural studies have defined many of the interactions that occur between individual components or subassemblies of the bacterial replicase, DNA polymerase III holoenzyme (Pol III HE). Here, we extended our knowledge of residues and interactions that are important for the first step of the replicase reaction: the ATP-dependent formation of an initiation complex between the Pol III HE and primed DNA. We exploited a genetic selection using a dominant negative variant of the… CONTINUE READING

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