DNA-PKcs is critical for telomere capping.

  title={DNA-PKcs is critical for telomere capping.},
  author={David R Gilley and Hiromitsu Tanaka and M. Prakash Hande and Akihiro Kurimasa and Gloria C. Li and Mitsuo Oshimura and David J. Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 26},
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is critical for DNA repair via the nonhomologous end joining pathway. Previously, it was reported that bone marrow cells and spontaneously transformed fibroblasts from SCID (severe combined immunodeficiency) mice have defects in telomere maintenance. The genetically defective SCID mouse arose spontaneously from its parental strain CB17. One known genomic alteration in SCID mice is a truncation of the extreme carboxyl terminus of DNA… CONTINUE READING


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Publications referenced by this paper.

Genome Analysis: a Laboratory Manual, Cold Spring Harbor

  • B. Birren, E. D. Green, S. Klapholz, R. M. Myers, J. Roskams
  • New York. Cold Spring Harbor Laboratory
  • 1997

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