DNA-PKcs associates with PLK1 and is involved in proper chromosome segregation and cytokinesis.

@article{Huang2014DNAPKcsAW,
  title={DNA-PKcs associates with PLK1 and is involved in proper chromosome segregation and cytokinesis.},
  author={Bo Huang and Z Shang and Bing Li and Yu Wang and Xiao-Dan Liu and Shi-Meng Zhang and Hua Guan and Wei-qing Rang and Jian-an Hu and Pingkun Zhou},
  journal={Journal of cellular biochemistry},
  year={2014},
  volume={115 6},
  pages={1077-88}
}
Accurate mitotic regulation is as important as intrinsic DNA repair for maintaining genomic stability. It is believed that these two cellular mechanisms are interconnected with DNA damage. DNA-PKcs is a critical component of the non-homologous end-joining pathway of DNA double-stranded break repair, and it was recently discovered to be involved in mitotic processing. However, the underlying mechanism of DNA-PKcs action in mitotic control is unknown. Here, we demonstrated that depletion of DNA… CONTINUE READING
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