DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells.

@article{Mukherjee2006DNAPKPH,
  title={DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells.},
  author={Bipasha Mukherjee and Chase W. Kessinger and Junya Kobayashi and Benjamin P. C. Chen and David J. Chen and Aloke Chatterjee and Sandeep Burma},
  journal={DNA repair},
  year={2006},
  volume={5 5},
  pages={575-90}
}
The phosphorylation of histone H2AX at serine 139 is one of the earliest responses of mammalian cells to ionizing radiation-induced DNA breaks. DNA breaks are also generated during the terminal stages of apoptosis when chromosomal DNA is cleaved into oligonucleosomal pieces. Apoptotic DNA fragmentation and the consequent chromatin condensation are important for efficient clearing of genomic DNA and nucleosomes and for protecting the organism from auto-immmunization and oncogenic transformation… CONTINUE READING