DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

  title={DNA-PK is a DNA sensor for IRF-3-dependent innate immunity},
  author={Brian J Ferguson and Daniel Santos Mansur and Nicholas E. Peters and Hongwei Ren and Geoffrey L Smith},
Innate immunity is the first immunological defence against pathogens. During virus infection detection of nucleic acids is crucial for the inflammatory response. Here we identify DNA-dependent protein kinase (DNA-PK) as a DNA sensor that activates innate immunity. We show that DNA-PK acts as a pattern recognition receptor, binding cytoplasmic DNA and triggering the transcription of type I interferon (IFN), cytokine and chemokine genes in a manner dependent on IFN regulatory factor 3 (IRF-3… CONTINUE READING
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