DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression

@article{Perillo2008DNAOA,
  title={DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression},
  author={Bruno Perillo and Maria Neve Ombra and Alessandra Bertoni and Concetta Cuozzo and Silvana Sacchetti and Anna Sasso and Lorenzo Chiariotti and Antonio Malorni and Ciro Abbondanza and Enrico Avvedimento},
  journal={Science},
  year={2008},
  volume={319},
  pages={202 - 206}
}
Modifications at the N-terminal tails of nucleosomal histones are required for efficient transcription in vivo. We analyzed how H3 histone methylation and demethylation control expression of estrogen-responsive genes and show that a DNA-bound estrogen receptor directs transcription by participating in bending chromatin to contact the RNA polymerase II recruited to the promoter. This process is driven by receptor-targeted demethylation of H3 lysine 9 at both enhancer and promoter sites and is… 

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