DNA Nanoparticles for Improved Protein Synthesis In Vitro

  title={DNA Nanoparticles for Improved Protein Synthesis In Vitro},
  author={Robertas Galinis and Greta Stonyte and Vaidotas Kiseliovas and Rapolas Zilionis and Sabine Studer and Donald Hilvert and A. Janulaitis and Linas Mazutis},
  booktitle={Angewandte Chemie},
The amplification and digital quantification of single DNA molecules are important in biomedicine and diagnostics. Beyond quantifying DNA molecules in a sample, the ability to express proteins from the amplified DNA would open even broader applications in synthetic biology, directed evolution, and proteomics. Herein, a microfluidic approach is reported for the production of condensed DNA nanoparticles that can serve as efficient templates for in vitro protein synthesis. Using phi29 DNA… CONTINUE READING
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